Combined oral contraceptive containing drospirenone does not modify 24-h ambulatory blood pressure but increases heart rate in healthy young women: prospective study

详细信息    查看全文

• 作者：Angelo Cagnacci ; Serena Ferrari ; Antonella Napolitano ; Ilaria Piacenti ; Serenella Arangino ; Annibale Volpe
• 关键词：Blood pressure ; Heart rate ; Hypertension ; Oral contraceptives ; Drospirenone ; Diurnal ; Ambulatory monitoring
• 刊名：Contraception
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：88
• 期：3
• 页码：413-417
• 全文大小：204 K

文摘

Background

Hypertension is a primary cardiovascular risk factor. Oral contraceptives (OCs) may increase blood pressure and cardiovascular events. We evaluated whether an OC containing ethynylestradiol (EE) in association with the spironolactone-derived progestin drospirenone (DRSP) influences 24-h ambulatory blood pressure of normotensive women.

Study Design

Twenty-four-hour blood pressure was measured every 30 min by an ambulatory blood pressure device in 18 normotensive healthy women prior to and after 6 months of use of an OC containing 30 mcg EE and 3 mg DRSP.

Results

OC induced no modification in 24-h, nighttime and daytime blood pressure. Heart rate increased about 4 beats/min in the 24-h (p<.05) and daytime (p<.02) measurements.

Conclusions

In normotensive women, an OC containing 30 mcg EE plus 3 mg DRSP does not modify blood pressure, and significantly increases 24-h and daytime heart rate. These data suggest a neutral effect on hypertension-associated cardiovascular risk and point out an unreported effect on heart rate of which cause and effect require further evaluation.