Immunogenicity of dimorphic and C-terminal fragments of Plasmodium falciparum MSP2 formulated with different adjuvants in mice
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- 作者：Saidou Balama ; balamsira@yahoo.fr" class="auth_mail" title="E-mail the corresponding author ; Ali Jafarshadb ; ajafarshad@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Catherine Servisa ; Ekaterini.Servi@unil.ch" class="auth_mail" title="E-mail the corresponding author ; Geraldine Franka ; geraldine.frank@unil.ch" class="auth_mail" title="E-mail the corresponding author ; Steve Reedc ; Steven.Reed@idri.org" class="auth_mail" title="E-mail the corresponding author ; Richard Pinka ; pinkr@mail.com" class="auth_mail" title="E-mail the corresponding author ; Pierre Druilheb ; druilhe@vac4all.org" class="auth_mail" title="E-mail the corresponding author ; Franç ; ois Spertinid ; francois.spertini@chuv.ch" class="auth_mail" title="E-mail the corresponding author ; Giampietro Corradina ; giampietro.corradin@unil.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：P. falciparum ; MSP2 ; Dimorphic region ; Constant region ; Immunogenicity ; Adjuvant
- 刊名：Vaccine
- 出版年：2016
- 出版时间：18 March 2016
- 年：2016
- 卷：34
- 期：13
- 页码：1566-1574
- 全文大小：1999 K
文摘
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Both dimorphic (D) and C region fragments of the two allelic families of MSP2 are immunogenic.
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The fine specificity and intensity of the antibodies responses are dependent on mouse strains and adjuvants.
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The major epitopes are restricted to the sequences comprising the last 8 aa of D and first 12 aa of C of the two allelic families and the first 20 aa of the C region.
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Strong immune responses were associated with GLA-SE adjuvant and its combination with other TLR agonists.
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And elicited antibodies are active in ADCI for Plasmodium falciparum growth inhibition.