A Deathly DNase Activity for Dicer

详细信息    查看全文

• 作者：Katsutomo Okamura ; Eric C. Lai
• 刊名：Developmental Cell
• 出版年：2010
• 出版时间：18 May 2010
• 年：2010
• 卷：18
• 期：5
• 页码：692-694
• 全文大小：223 K

文摘

Recently reporting in Science, Nakagawa et al. describe an unexpected role for Dicer in chromosome fragmentation during apoptosis in C. elegans. They find that cleavage of DCR-1 by the caspase CED-3 redirects its regulatory activity, by destroying its dsRNase activity while activating an intrinsic DNase activity.