Reciprocal interaction among gasotransmitters in isolated pancreatic β-cells
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- 作者：Amira Moustafaa ; b ; Yoshiaki Habaraa ; habara@vetmed.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AOAA ; amino-oxyacetic acid ; [Ca2+]i ; intracellular Ca2+ concentration ; 3MST ; 3-mercatopyruvate sulfurtransferase ; CaM ; calmodulin ; CBS ; Cystathionine-β-synthetase ; CO ; carbon monoxide ; CSE ; cystathionine-γ-lyase ; deoxy-Mb ; deoxymyoglobin ; DTZ ; dithizone ; eNOS ; endothelial NOS ; F.I. ; fluorescence intensity ; H2S ; hydrogen sulfide ; HBSS ; Hank's Balanced Salt Solution ; HOs ; heme oxygenases ; iNOS ; inducible NOS ; L-NMMA ; NG-Monomethyl-L-arginine ; MbCO ; carbonmonoxy myoglobin ; NaHS ; sodium hydrosulfide
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：47-58
- 全文大小：3931 K
文摘
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Potential interaction between NO, CO and H2S, was evaluated in pancreatic β cells.
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One of NO, CO and H2S could reciprocally produce other two gases.
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NO–, CO– and H2S-producing enzymes were expressed in β cells.
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NO, CO and H2S induced intracellular Ca2+ increase in a dose-dependent manner.
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NO stimulated and CO inhibited basal insulin release but H2S had no effect.