Depletion of the AMPAR reserve pool impairs synaptic plasticity in a model of hepatic encephalopathy
详细信息 查看全文
- 作者：Annett Schroetera ; 1 ; Shuping Wena ; 1 ; Andrea Mö ; ldersa ; Nadine Erlenhardta ; Valentin Steinb ; Nikolaj Klö ; ckera ; nikolaj.kloecker@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatic encephalopathy ; Ammonia ; Glutamatergic neurotransmission ; AMPA receptor ; NMDA receptor ; LTP ; LTD ; Neuroglial co-culture
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：68
- 期：Complete
- 页码：331-339
- 全文大小：1178 K
文摘
- class="listitem" id="list_l0015">
- class="label">•
Chronic exposure to ammonia reduces neuronal AMPAR expression
- class="label">•
Neurons maintain basal glutamatergic transmission at the expense of the extrasynaptic receptor population
- class="label">•
Synaptic plasticity is impaired by the consumption of the extrasynaptic AMPAR reserve under conditions of high ammonia