Development of a phenotypic susceptibility assay for HIV-1 integrase inhibitors
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- 作者：Eva Hegera ; Alexandra André ; e Theisa ; Klaus Remmela ; Hauke Walterb ; Alejandro Pirontic ; Elena Knopsa ; Veronica Di Cristanzianoa ; Bjö ; rn Jensend ; Stefan Essere ; Rolf Kaisera ; Nadine Lü ; bkea ; 1 ; nadine.luebke@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIV-1 ; Integrase ; Phenotypic resistance ; Geno2pheno ; Cross-resistance ; Dolutegravir
- 刊名：Journal of Virological Methods
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：238
- 期：Complete
- 页码：29-37
- 全文大小：1269 K
文摘
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Establishment of a recombinant phenotypic HIV-1 integrase susceptibility assay.
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Resistance analysis of the integrase gene of patient-derived viruses in vitro.
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Generation of resistance data after therapy failures from routine clinical practice.
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Possibility to identify resistance patterns of recent integrase inhibitors.
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Generation of additional genotype-phenotype pairs for geno2pheno[integrase].