Carotid intima media thickness is associated with plasma adiponectin but not with the leptin:adiponectin ratio independently of metabolic syndrome

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• 作者：Robin P.F. Dullaart ; Paul J.W.H. Kappelle ; Geesje M. Dallinga-Thie
• 关键词：Adiponectin ; Intima media thickness ; Leptin ; Leptin ; adiponectin ratio ; Metabolic syndrome
• 刊名：Atherosclerosis
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：211
• 期：2
• 页码：393-396
• 全文大小：101 K

文摘

Purpose

A recent report showed no benefit of the leptin:adiponectin ratio (L:A ratio) over individual adipokine levels in CHD prediction [8]. We determined associations of carotid intima media thickness (IMT) with the L:A ratio taking account of cardiovascular risk factors in a high risk population.

Methods

<p>IMT, plasma leptin, adiponectin and the L:A ratio were determined in 161 middle-aged men and women (45 % metabolic syndrome).

Results

<p>IMT was associated inversely with adiponectin and positively with the L:A ratio in age- and sex-adjusted multiple linear regression analyses (P < 0.001 for both). After controlling for metabolic syndrome, the independent association with adiponectin remained (P < 0.001), but the relationship with the L:A ratio disappeared (P = 0.126). Results were similar after additional adjustment for diabetes status or for insulin resistance.

Conclusion

<p>This study does not support the preferential use of the leptin:adiponectin ratio as a marker of atherosclerosis susceptibility.