Common variation in Cholesteryl Ester Transfer Protein: Relationship of first major adverse cardiovascular events with the apolipoprotein B/apolipoprotein A-I ratio and the total cholesterol/high-density lipoprotein cholesterol ratio

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• 作者：Paul J.W.H. Kappelle ; MDp>ap> ; Ron T. Gansevoort ; MD ; PhDp>bp> ; Hans J. Hillege ; MD ; PhDp>cp> ; Bruce H.R. Wolffenbuttel ; MD ; PhDp>ap> ; Robin P.F. Dullaart ; MD ; PhDp>ap>p> ; p>p>r.p.f.dullaart@umcg.nlp> ; PREVEND Study Group
• 关键词：Apolipoprotein A-I ; Apolipoprotein B ; Cardiovascular risk ; Cholesteryl Ester Transfer Protein gene ; HDL cholesterol ; Non-HDL cholesterol
• 刊名：Journal of Clinical Lipidology
• 出版年：2013
• 出版时间：January-February, 2013
• 年：2013
• 卷：7
• 期：1
• 页码：56-64
• 全文大小：155 K

文摘

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Background

The preference of the apolipoprotein (apo) B/apoA-I ratio over the total cholesterol/HDL cholesterol (TC/HDL-C) ratio in cardiovascular risk prediction is disputed. Cholesteryl ester transfer protein (CETP) is instrumental in lipoprotein remodelling and affects the cholesterol content in pro- and antiatherogenic lipoproteins relative to their major apolipoproteins. We tested the influence of common CETP variations on the strength of associations of a first major adverse cardiovascular event (MACE) with the apoB/apoA-I ratio compared with the TC/HDL-C ratio.

Methods

<p>A prospective case-cohort study was performed (PREVEND cohort; no previous cardiovascular disease and no use of lipid-lowering drugs initially). Fasting serum TC/HDL-C, apoB/apoA-I, triglycerides, and common CETP variations (TaqIB [rs708272] and -629C>A [rs1800775] polymorphisms) were measured at baseline. The composite end point was incident MACE.

Results

<p>A total of 532 of 6780 subjects experienced a first MACE during 10.8 years follow-up. The age- and sex-adjusted hazard ratio was 1.31 (95 % confidence interval 1.23-1.41) for the apoB/apoA-I ratio and 1.22 (95 % confidence interval 1.26-1.39) for the TC/HDL-C ratio (both P < .001). These relationships were essentially similar within each TaqIB and -629C>A CETP genotype group. No interactions of the apoB/apoA-I ratio and the TC/HDL-C ratio with the TaqIB and the -629C>A CETP variations on incident MACE were observed (P > .20 for all).

Conclusion

<p>The relationship of first MACE with the TC/HDL-C and the apoB/apoA-I ratio is not?to an important extent dependent on common CETP variations. CETP variations are unlikely to affect?the strength of the relationship of first MACE with the apoB/apoA-I ratio compared with the TC/HDL-C ratio.