- 作者：Andrea Salonia ; Arthur L. Burnett ; Markus Graefen ; Kostas Hatzimouratidis ; Francesco Montorsi ; John P. Mulhall ; Christian Stief
- 关键词：Radical prostatectomy ; Erectile function ; Erectile dysfunction ; Phosphodiesterase-5 inhibitors ; Intracavernosal injection ; Penile prosthesis ; Sexual desire ; Orgasmic function ; Climacturia
- 刊名：European Urology
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：62
- 期：2
- 页码：273-286
- 全文大小：268 K
Context
Sexual dysfunction is common in patients who undergo radical prostatectomy (RP) for prostate cancer (PCa).Objective
Review the available literature concerning prevention of, and management strategies for, post-RP sexual dysfunction in terms of postoperative treatments for erectile function (EF), sexual desire (SD), and orgasmic function (OF) impairment.
Evidence acquisition
A literature search was performed using Google and PubMed databases for English language original and review articles either published or e-published up to November 2011.
Evidence synthesis
We propose a rational description of many of the clinically available preventive and therapeutic strategies for the preservation and recovery of post-RP EF. A huge amount of preclinical data show that tissue damage ultimately leads to structural alterations, and the literature stresses that rehabilitation and treatment are undoubtedly better than leaving the erectile tissue to its unassisted fate; likewise, the timing of any rehabilitation and treatment is of major clinical importance. However, no specific recommendation emerges regarding the structure of the optimal rehabilitation or treatment regimen. The role of postoperative erectile dysfunction (ED) treatment of those patients who received a non-nerve-sparing RP was also extensively discussed. The literature almost completely lacks a systematic and comprehensive debate about SD (ie, low libido) and OF (ie, decreased intensity of orgasm, dysorgasmia, and climacturia) in patients undergoing RP. Psychological and sexual counseling is of major importance to improve any rehabilitation and treatment of postoperative EF, SD, and OF impairment.
Conclusions
Despite the great number of possible rehabilitation approaches proposed, these approaches should be considered only as strategies, since incontrovertible evidence of their effectiveness for improving natural EF recovery is limited. Conversely, numerous effective therapeutic options are available for treating post-RP ED. SD and OF have not yet been fully assessed in patients who underwent RP.