Retinal proteome changes following experimental branch retinal vein occlusion and intervention with ranibizumab
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- 作者：Lasse Jø ; rgensen Cehofskia ; b ; c ; L.cehofski@rn.dk" class="auth_mail" title="E-mail the corresponding author ; Anders Krusea ; Martin Bø ; gstedc ; d ; Sigrið ; ur Olga Magnusdottirb ; Allan Stensballee ; Bent Honoré ; c ; f ; Henrik Voruma ; c
- 关键词：Biological marker ; Mass spectrometry ; Protein ; Proteomics ; Ranibizumab ; Retina ; Retinal vein occlusion ; Vascular endothelial growth factor ; Integrin
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：152
- 期：Complete
- 页码：49-56
- 全文大小：1136 K
文摘
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The content of integrin β-1 was decreased following treatment with Ranibizumab.
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Calnexin and 40S ribosomal protein S5 decreased in content when VEGF-A was blocked.
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OCIA domain-containing protein 1 was downregulated following inhibition of VEGF-A.
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A role of integrin β-1 in branch retinal vein occlusion is proposed.