Functional activity of L-carnitine transporters in human airway epithelial cells
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- 作者：Filippo Ingogliaa ; 1 ; Rossana Visigallia ; 1 ; Bianca Maria Rotolia ; Amelia Barillia ; Benedetta Riccardib ; Paola Puccinib ; Valeria Dall'Astaa ; valeria.dallasta@unipr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATB0 ; + ; ; amino acid transporter B0 ; + ; ; EBSS ; Earle's Balanced Salt Solution ; OCTN ; novel organic cation transporter ; PBS ; phosphate-buffered saline solution
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1858
- 期：2
- 页码：210-219
- 全文大小：1016 K
文摘
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Carnitine transport in A549 and BEAS-2B cells is operated by the high affinity OCTN2.
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Carnitine transport in Calu-3 and NCl-H441 cells is operated by OCTN2 and ATB0,+.
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ATB0,+ activity leads to high intracellular concentrations of carnitine.
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ATB0,+ could provide cells with carnitine in patients carrying OCTN2 mutations.