Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma

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• 作者：Leopold Ludwig ; Franz Oswald ; Cuong Hoang-Vu ; Henning Dralle ; Eberhard Hildt ; Rol ; M. Schmid ; Wolfram Karges
• 关键词：Thyroid ; Cancer ; Tyrosine kinase ; Expression ; Oncogene
• 刊名：Cancer Letters
• 出版年：2009
• 出版时间：18 March 2009
• 年：2009
• 卷：275
• 期：2
• 页码：194-197
• 全文大小：188 K

文摘

Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration in genomic Grap-2 sequence. Consistent Grap-2 expression suggests a specific role for this adaptor in human MTC, while qualitative alterations do not appear to influence RET signaling.