伪-Synuclein and nonhuman primate models of Parkinson's disease
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- 作者：Scott C. Vermilyeaa ; b ; svermilyea@primate.wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Marina E. Emborga ; b ; c ; emborg@primate.wisc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：伪-syn ; 伪-synuclein ; 6-OHDA ; 6-hydroxydopamine ; AAV2 ; adeno-associated viral vector serotype 2/2 ; ALP ; autophagy-lysosomal pathway ; BBB ; blood&ndash ; brain&ndash ; barrier ; c-hGH ; cadaver-derived human growth hormone ; CK ; casein kinases ; DA ; dopamine ; DAT ; dopamine acetyltransferase ; DLB ; disease with Lewy bodies ; ECFP ; enhance cyan fluorescent protein ; EPM1 ; progressive myoclonus epilepsy type 1 ; GFP ; green fluorescent protein ; GRKs ; G-protein-coupled receptor kinases ; IVF ; in vitro fertilization
- 刊名：Journal of Neuroscience Methods
- 出版年：2015
- 出版时间：30 November 2015
- 年：2015
- 卷：255
- 期：Complete
- 页码：38-51
- 全文大小：3400 K
文摘
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伪-Synuclein (伪-Syn) accumulation has a significant role in Parkinson's disease (PD).
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伪-Syn protein sequence is well conserved across species.
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Nigral 伪-syn distribution in monkeys changes with age or toxin exposure.
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Viral vector gene transfer of wild type or mutated 伪-syn induces neurodegeneration.
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Novel PD monkey models are being generated using inoculations of 伪-syn and transgenesis.