PICT-1 is a nucleolar protein that regulates cell fate and nucleolar stress response.
PICT-1 may function as a tumor suppressor or as an oncogene.
Self-association of PICT-1 is shown in yeast and in mammalian cells.
Microfluidic assays identified the carboxy-terminus as mediating self-interaction.
Another layer of complexity to the different functions of PICT-1 is added.