Downregulation of DNA methyltransferase 3 alpha promotes cell proliferation and invasion of ectopic endometrial stromal cells in adenomyosis

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• 作者：Yang Zou^a ; ^b ; ¹ ; Fa-Ying Liu^a ; ^b ; ¹ ; Li-Qun Wang^a ; ^c ; Jiu-Bai Guo^a ; ^c ; Bi-Cheng Yang^a ; Xi-Di Wan^a ; Feng Wang^a ; ^b ; Ming He^d ; ^{jxhm56@hotmail.com} ; Ou-Ping Huang^a ; ^c ; ^{jxfbhop@126.com}
• 关键词：DNMT3A ; DNA (cytosine-5)-methyltransferase 3A ; EECs ; endometrial epithelial cells ; ESCs ; endometrial stromal cells ; EEECs ; ectopic endometrial epithelial cells ; WB ; Western blotting ; IHC ; immunohistochemistry ; ACTB ; beta-actin ; FFPE ; formalin fixed paraffin embedded ; CCK-8 ; Cell Counting Kit-8 ; OD ; optical density
• 刊名：Gene
• 出版年：2017
• 出版时间：10 March 2017
• 年：2017
• 卷：604
• 期：Complete
• 页码：41-47
• 全文大小：811 K
• 卷排序：604

文摘

DNMT3A expression was decreased in ectopic endometriums in adenomyosis relative to that of eutopic endometriums in control samples. DNMT3A expression was significantly decreased in EESCs in adenomyosis relative to that of EESCs in control samples. We provided the first evidence that decreased expression of DNMT3A in EESCs facilitated adenomyosis via enhanced cell proliferation and invasion.