Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis

详细信息    查看全文

• 作者：Diego Veras Wilke ; Paula Christine Jimenez ; Renata Mendonç ; a Araú ; jo ; Wildson Max Barbosa da Silva ; Otí ; lia Deusdê ; nia Loiola Pessoa ; Edilberto Rocha Silveira ; Claudia Pessoa ; Manoel O
• 关键词：Protopalythoa variabilis ; Lipidic α ; -amino acids ; Cytotoxicity ; Apoptosis
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2010
• 出版时间：15 November 2010
• 年：2010
• 卷：18
• 期：22
• 页码：7997-8004
• 全文大小：731 K

文摘

Lipidic α-amino acids (LAAs) have been described as non-natural amino acids with long saturated or unsaturated aliphatic chains. In the continuing prospect to discover anticancer agents from marine sources, we have obtained a mixture of two cytotoxic LAAs (1a and 1b) from the zoanthid Protopalythoa variabilis. The anti-proliferative potential of 14 synthetic LAAs and 1a/1b were evaluated on four tumor cell lines (HCT-8, SF-295, MDA-MB-435, and HL-60). Five of the synthetic LAAs showed high percentage of tumor cell inhibition, while 1a/1b completely inhibited tumor cell growth. Additionally, apoptotic effects of 1a/1b were studied on HL-60 cell line. 1a/1b-treated cells showed apoptosis morphology, loss of mitochondrial potential, and DNA fragmentation.