Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules

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• 作者：Hae Woong Choi¹ ; ¹⁰ ; ¹¹ ; ^{haewoong.choi@duke.edu} ; Samantha E. Bowen² ; ¹⁰ ; Yuxuan Miao² ; Cheryl Y. Chan⁴ ; Edward A. Miao⁵ ; ⁶ ; ⁷ ; Magnus Abrink⁸ ; Adam J. Moeser⁹ ; Soman N. Abraham¹ ; ² ; ³ ; ⁴
• 关键词：mast cells ; bladder epithelial cells ; cytolytic granules ; chymase ; exfoliation ; uropathogenic E. coli ; inflammasome ; caspase 1 ; cytolysis ; IL-1β
• 刊名：Immunity
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：45
• 期：6
• 页码：1258-1269
• 全文大小：4190 K
• 卷排序：45

文摘

Mast cells trigger bladder epithelial cell (BEC) exfoliation during E. coli infection During infection, BECs secrete interleukin-1β, which recruits mast cells Mast cells release granules that are endocytosed by BECs triggering lytic death Mast cell chymase is the critical component in granules causing cell death