Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response

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• 作者：Michael B. Lazarus¹ ; Rebecca S. Levin ; Kevan M. Shokat ; ^{kevan.shokat@ucsf.edu}
• 关键词：eEF2K ; eEF2 ; Translation elongation ; Energy homeostasis ; alpha4 ; AMPK
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：78-83
• 全文大小：515 K
• 卷排序：29

文摘

eEF2K has multiple substrates beyond eEF2, including AMPK and alpha4. Atypical kinases can be made analog sensitive for discovering new substrates. eEF2K has an unusual substrate motif that requires threonine.