Effects of acute caffeine on anxiety-related behavior in rats chronically exposed to the drug, with some evidence of possible withdrawal-reversal
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- 作者：Robert N. Hughes ; rob.hughes@canterbury.ac.nz ; Nicola J. Hancock
- 关键词：Chronic acute caffeine ; Rats ; Anxiety ; Spatial memory ; Withdrawal reversal ; Sex differences
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 March 2017
- 年：2017
- 卷：321
- 期：Complete
- 页码：87-98
- 全文大小：3206 K
- 卷排序：321
文摘
Chronic caffeine decreased activity, increased anxiety and had no effect on spatial memory. Acute caffeine in caffeine-naïve rats increased activity and may have reduced anxiety. Acute caffeine had similar effects on caffeine-exposed rats to those for naïve rats. Some acute effects on caffeine-exposed rats may have involved withdrawal reversal. Some chronic and acute caffeine effects depended on the rats sex.