Efficacy assessment of an inactivated Tembusu virus vaccine candidate in ducks

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• 作者：Lijiao Zhang^a ; Zhanhong Li^a ; Qingshui Zhang^a ; Mengxu Sun^a ; Shuang Li^b ; Wenliang Su^a ; Xueying Hu^c ; Weiyong He^a ; Jingliang Su^a ; ^{suzhang@cau.edu.cn}
• 关键词：Tembusu virus ; Flavivirus ; Inactivated vaccine ; Duck ; Beta-propiolactone (BPL) ; Cell culture
• 刊名：Research in Veterinary Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：72-78
• 全文大小：678 K
• 卷排序：110

文摘

Duck TMUV can propagate efficiently on a baby hamster kidney cell line (BHK-21). β-Propiolactone (BPL) is more effective than formaldehyde used to inactivate TMUV. BPL-inactivated TMUV vaccine provided high protective efficacy in TMUV-challenged ducks. We provide a scientific basis for commercial inactivated TMUV vaccine development.