Histone deacetylase inhibitor abexinostat affects chromatin organization and gene transcription in normal B cells and in mantle cell lymphoma

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• 作者：Diana Markozashvili^a ; ^b ; Andrei Pichugin^a ; ^b ; ^c ; Ana Barat^a ; ^b ; Valerie Camara-Clayette^d ; Natalia V. Vasilyeva^e ; Hé ; l&egrave ; ne Leli&egrave ; vre^f ; Laurence Kraus-Berthier^f ; Sté ; phane Depil^f ; Vincent Ribrag^d ; Yegor Vassetzky^a ; ^b ; ^g ; ^{vassetzky@igr.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BL ; Burkitt's lymphoma ; CCND1 ; cyclin D1 gene ; DNA ; deoxyribonucleic acid ; FISH ; fluorescence in situ hybridization ; HDAC ; histone deacetylase ; HDACi ; histone deacetylase inhibitor ; LCL ; lymphoblastoid cell line ; MCL ; mantle cell lymphoma ; NBL ; normal B-lymphocytes ; qRT-PCR ; quantitative real-time polymerase chain reaction ; TSA ; trychostatin A
• 刊名：Gene
• 出版年：2016
• 出版时间：15 April 2016
• 年：2016
• 卷：580
• 期：2
• 页码：134-143
• 全文大小：1054 K

文摘

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d="p0005">Translocation (11;14) leads to upregulation of a cluster of genes located on both sides of the translocation point.

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d="p0010">H3K9 acetylation status of this locus is elevated as compared to the average genome acetylation level.

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d="p0015">Abexinostat provokes a general heterochromatin disaggregationt, but only a small subset of genes reacts to the treatment.

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d="p0020">Abexinostat-triggered effects on genes located in the t(11:14) translocation region had a non-epigenetic nature.

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d="p0025">CD6, CD5, CTSF, and ORAOV1 are overexpressed in MCL; they can be considered as potential targets for MCL therapy.

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