Squamous cell carcinoma of buccal mucosa: a 40-year review

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• 作者：Adam DeConde ; MD^a ; ^{adeconde@mednet.ucla.edu} ; Mia E. Miller ; MD^a ; Beth Palla ; MD^b ; Chi Lai ; MD^b ; David Elashoff ; PhD^c ; ^d ; Dinesh Chhetri ; MD^a ; Maie A. St. John ; MD ; PhD^a ; ^d
• 刊名：American Journal of Otolaryngology
• 出版年：2012
• 出版时间：November-December, 2012
• 年：2012
• 卷：33
• 期：6
• 页码：673-677
• 全文大小：158 K

文摘

Purpose

The aim of this study was to analyze the outcome of surgical therapy for buccal squamous cell carcinoma (SCCA) at a single tertiary care institution during a 40-year period.

Materials and methods

A retrospective review was performed by examining the records and pathology of 48 patients with buccal SCCA treated at a single tertiary care institution from 1970 to 2009.

Results

Treatment entailed surgery alone in 18 patients (37.5 % ) and surgery followed by radiation therapy in 30 patients (62.5 % ). Composite resection was performed in 17 patients (35.4 % ), and ipsilateral neck dissections were performed in 37patients (77.1 % ). One-year observed actuarial disease-free survival rates were 60 % , 46 % , 0 % , and 40 % for T1 through T4, respectively. Univariate analysis revealed increased age as a risk factor for disease recurrence (P = .062), with skin taken and neck dissection not achieving significance (P = .24 and .20, respectively). Multivariate analysis demonstrated age as increasing risk and neck dissection as decreasing risk of recurrence (P = .029 and .023, respectively).

Conclusions

We report relatively high disease-free survival rates in patients who underwent aggressive resection and neck dissection. Performance of neck dissection and younger age were associated with a favorable prognosis. Performance of neck dissection may decrease the risk of recurrence in primary SCCA of the buccal mucosa. Although through-and-through resection of skin decreased risk of disease recurrence, this difference is not statistically significant (P = .24).