MicroRNAs in the thyroid

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• 作者：Myriem Boufraqech ; PhD^a ; ¹ ; Joanna Klubo-Gwiezdzinska ; MD ; PhD^b ; ¹ ; Electron Kebebew ; MD^a ; ^{kebebewe@mail.nih.gov}
• 关键词：microRNA ; thyroid cancer ; diagnosis ; prognosis ; treatment ; circulating microRNA
• 刊名：Best Practice & Research Clinical Endocrinology & Metabolism
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：30
• 期：5
• 页码：603-619
• 全文大小：695 K
• 卷排序：30

文摘

MicroRNAs (miRNAs) are small non-coding RNA comprising approximately 19–25 nucleotides. miRNAs can act as tumour suppressors or oncogenes, and aberrant expression of miRNAs has been reported in several human cancers and has been associated with cancer initiation and progression. Recent evidence suggests that miRNAs play a major role in thyroid carcinogenesis. In this review, we summarize the role of miRNAs in thyroid cancer and describe the oncogenic or tumour suppressor function of miRNAs as well as their clinical utility as prognostic or diagnostic markers in thyroid cancer.