Glassy carbon electrode modified with 3D graphene-carbon nanotube network for sensitive electrochemical determination of methotrexate
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A novel 3D graphene–carbon nanotube network was constructed on the surface of glassy carbon electrode through a simple and effective electrodeposition approach.

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The prepared 3D interpenetrated graphene-CNT network was successfully used for electrochemical determination of Methotrexate (MTX).

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The improved electrochemical performance is ascribed to the large accessible surafce area of the interpenetrated 3DG network as well as its enhanced electrical conductivity by incorporating CNTs.

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The proposed method can determine MTX in a wide dynamic linear range with a low detection limit.

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The superior properties of the proposed sensing platform make it very suitable for electrochemical determination of MTX in pharmaceutical formulations and clinical preparations.

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