Alzheimer's disease patients not carrying the apolipoprotein E ¦Å4 allele show more severe slowing of oscillatory brain activity

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• 作者：Hanneke de Waal^a ; ^{h.dewaal@vumc.nl} ; Cornelis J. Stam^b ; Willem de Haan^a ; Elisabeth C.W. van Straaten^b ; Marinus A. Blankenstein^c ; Philip Scheltens^a ; Wiesje M. van der Flier^a ; ^d
• 关键词：Alzheimer's disease ; APOE genotype ; Resting-state EEG ; Quantitative analysis
• 刊名：Neurobiology of Aging
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：34
• 期：9
• 页码：2158-2163
• 全文大小：617 K

文摘

The objective of this study was to quantitatively assess the relationship between apolipoprotein (APOE) genotype and electroencephalographic oscillatory brain dynamics in Alzheimer's disease (AD) patients and control subjects and its regional distribution. We obtained resting-state electroencephalographs of 320 AD patients and 246 control subjects, categorized into APOE ¦Å4 carriers and noncarriers. Peak frequency and relative power in 4 different frequency bands were calculated. We tested the associations between APOE genotype and relative power in 4 brain regions. Peak frequency was comparable in APOE ¦Å4 carrying and noncarrying control subjects, but lower in APOE ¦Å4 noncarrying AD patients. In control subjects, APOE ¦Å4 carriers had a different regional distribution of alpha power than noncarriers. We found no APOE effect in beta, delta, and theta bands. In AD, APOE ¦Å4 noncarriers had lower alpha and higher delta power than carriers. This difference was most pronounced in the parieto-occipital region. In the theta band, APOE ¦Å4 noncarriers had a different regional distribution of power compared with carriers. In conclusion, the most pronounced effect of genotype was seen in AD patients, and APOE ¦Å4 noncarriers showed slower activity, especially in parieto-occipital regions.