Co-occurrence of neuroblastoma and nephroblastoma in an infant with Fanconi's anemia

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• 作者：Heidi Bissig ; Franziska Staehelin ; Markus Tolnay ; Pierino Avoledo ; Jan Richter ; David Betts ; Elisabeth Bruder ; Thomas K[uuml ]hne
• 刊名：Human Pathology
• 出版年：2002
• 出版时间：October 2002
• 年：2002
• 卷：33
• 期：10
• 页码：1047-1051
• 全文大小：468 K

文摘

We report the clinical, histologic, and genetic findings of concurrent neuroblastoma and nephroblastoma in an infant with Fanconi's anemia (FA). Both tumors had characteristic chromosomal aberrations. In particular, the neuroblastoma showed a gain of chromosome 17q, considered an important factor for prognosis. But untypical genetic changes were also seen suggesting that FA as a chromosomal instability syndrome causes new and untypical chromosomal variations in different tumors. The present case is unique because the simultaneous occurrence of a neuroblastoma and nephroblastoma with FA has not yet been described. H P 33:1047-1051.