Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring
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- 作者：Fair M. Vassoler ; fair.vassoler@tufts.edu" class="auth_mail" title="E-mail the corresponding author ; Siobhan J. Wright ; Elizabeth M. Byrnes
- 关键词：Opiates ; Opioids ; Conditioned place preference ; Adolescence ; Morphine ; Sensitization ; Transgenerational ; Mu opioid receptor ; VTA ; NAc
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：103
- 期：Complete
- 页码：112-121
- 全文大小：1123 K
文摘
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Adult offspring of females exposed to morphine during adolescence are studied.
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Offspring demonstrate enhanced sensitivity to the rewarding properties of morphine.
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Mu opioid receptors of offspring are altered in the nucleus accumbens.
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Mu opioid receptors of offspring are altered in the ventral tegmental area.