Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

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• 作者：Megumi Hatori¹ ; ⁴ ; Christopher Vollmers¹ ; ⁴ ; Amir Zarrinpar¹ ; ² ; ⁴ ; Luciano DiTacchio¹ ; ⁴ ; Eric  ; A. Bushong³ ; Shubhroz Gill¹ ; Mathias Leblanc¹ ; Amandine Chaix¹ ; Matthew Joens¹ ; James  ; A.J. Fitzpatrick¹ ; Mark  ; H. Ellisman³ ; Satchidananda Panda¹ ; ^{satchin@salk.edu}
• 刊名：Cell Metabolism
• 出版年：2012
• 出版时间：6 June, 2012
• 年：2012
• 卷：15
• 期：6
• 页码：848-860
• 全文大小：1928 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences<h3 class=""h3"">Summaryh3>While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8?hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. The tRF regimen improved CREB, mTOR, and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome and improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a nonpharmacological strategy against obesity and associated diseases.