NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
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- 作者：Zhenyu Zhong1 ; 2 ; 10 ; Atsushi Umemura1 ; 2 ; 3 ; 10 ; Elsa Sanchez-Lopez1 ; 2 ; Shuang Liang4 ; Shabnam Shalapour1 ; 2 ; Jerry Wong1 ; 2 ; Feng He1 ; 2 ; Daniela Boassa5 ; Guy Perkins5 ; Syed Raza Ali6 ; Matthew D. McGeough6 ; Mark H. Ellisman5 ; Ekihiro Seki4 ; 7 ; Asa B. Gustafsson8 ; Hal M. Hoffman6 ; Maria T. Diaz-Meco9 ; Jorge Moscat9 ; Michael Karin1 ; 2 ; karinoffice@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：25 February 2016
- 年：2016
- 卷：164
- 期：5
- 页码：896-910
- 全文大小：6092 K
文摘
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NF-κB mediates LPS-induced p62/SQSTM1 expression in macrophages
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NLRP3 agonists damage mitochondria and release inflammasome activating signals
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Ubiquitinated damaged mitochondria are eliminated by p62-dependent mitophagy
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p62 ablation prevents mitophagy and enhances NLRP3-inflammasome activation