Micronucleus assay assessment of possible genotoxic effects in patients treated with titanium alloy endosseous implants or miniplates

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• 作者：Bensu Karahalil ; Ela Kadioglu ; Ay艧eg眉l M. Tuzuner-Oncul ; Emre Cimen ; Esra Emerce ; Reha S. Kisnisci
• 关键词：Titanium alloy ; Implant ; Genotoxicity ; Micronucleus ; Mucogingival cells ; DNA damage
• 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
• 出版年：15 January, 2014
• 年：2014
• 卷：760
• 期：Complete
• 页码：70-72
• 全文大小：428 K

文摘

The use of titanium and its alloys (Ti-6Al-4V) for oral surgery has increased dramatically in recent years. Ti is a stable biocompatible metal suitable for oral applications and it has been used for endosseous subperiosteal implants and miniplate fixation for more than 25 years. Dental implants are typically made of Ti or Ti alloys. The alloys are potentially toxic due to release of vanadium and aluminum. We tested the possible genotoxicity of Ti alloy endosseous implants and miniplates on the oral mucosal tissues of two groups of patients: 17 patients receiving Ti miniplate and screw fixation, and 37 endosseous dental implant placement patients. Preoperative and postoperative mucogingival cell samples were collected. Genotoxicity was assessed by the micronucleus assay (MN). There were slight but not statistically significant increases in the frequencies of MN (p = 0.087 and p = 0.047) post-operation in both groups. In summary, neither of the applications showed genotoxicity in the oral epithelial cells of patients.