Evidence of substance P autocrine circuitry that involves TNF-α, IL-6, and PGE2 in endogenous pyrogen-induced fever
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- 作者：Haissa Oliveira Britoa ; Felipe L. Barbosaa ; Renata Cristiane dos Reisa ; Daniel Fragaa ; 1 ; Beatriz S. Borgesb ; Celia R.C. Francob ; Aleksander Roberto Zampronioa ; aleksander@ufpr.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Substance P ; Cytokines ; Prostaglandin ; Endogenous opioids ; Corticotroin-releasing factor ; Endothelin-1
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：293
- 期：Complete
- 页码：1-7
- 全文大小：1090 K
文摘
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The role of substance P (SP) in endogenous pyrogen-induced fever was investigated.
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Substance P participates in fever that is induced by tumor necrosis factor α and interleukin-6.
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Substance P and prostaglandins participate of an autocrine circuitry to induce fever.
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Substance P is released after endotelin-1, endogenous opioid, and corticotropin-releasing factor release.
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Endotoxins and prostaglandins activate NK1 receptors in the hypothalamus.