Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice

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• 关键词：HK-1 ; hemokinin-1 ; EKA/B/C/D ; endokinin A/B/C/D ; SP ; substance P ; Tac1/2/3 ; preprotachykinin 1/2/3 gene ; NK1/2/3 ; tachykinin NK1/2/3 receptor ; Tacr1 ; tachykinin NK1 receptor encoding gene
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：219-232
• 全文大小：4781 K
• 卷排序：59

文摘

Hemokinin-1 exerts anxiolytic and anti-depressant-like actions in mouse models. Stress-induced neuronal activation is decreased in hemokinin-1-deficient mice. Deleting and blocking the NK-1 receptors decrease depression-like behavior. Hemokinin-1 regulates stress/depression via unknown target-mediated mechanisms.