Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G
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- 作者：Jason L.J. Lin1 ; 7 ; Akihisa Nakagawa2 ; 7 ; Riley Skeen-Gaar2 ; Wei-Zen Yang1 ; Pei Zhao3 ; Zhe Zhang3 ; Xiao Ge3 ; Shohei Mitani4 ; 5 ; Ding Xue2 ; 3 ; ding.xue@colorado.edu" class="auth_mail" title="E-mail the corresponding author ; Hanna S. Yuan1 ; 6 ; hanna@sinica.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：endonuclease G ; apoptosis ; nuclease ; mitochondria dysfunction ; crystal structure
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 July 2016
- 年：2016
- 卷：16
- 期：2
- 页码：279-287
- 全文大小：2850 K
文摘
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Mitochondrial EndoG/CPS-6 dimers shift to monomers under oxidating conditions
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The nuclease activity of EndoG/CPS-6 is diminished in response to high ROS levels
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AIF/WAH-1 acts as an antioxidant to stabilize the dimeric conformation of EndoG/CPS-6
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Oxidative stress impairs cell death through suppression of EndoG’s nuclease activity