Cladosporol A, a new peroxisome proliferator-activated receptor 纬 (PPAR纬) ligand, inhibits colorectal cancer cells proliferation through 尾-catenin/TCF pathway inactivation
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- 作者：Diana Zurloa ; Gemma Assanteb ; Salvatore Moriccac ; Vittorio Colantuonia ; Angelo Lupoa ; lupo@unisannio.it" class="auth_mail
- 关键词：CRC ; colorectal cancer ; PPARs ; peroxisome proliferators-activated receptors ; PPAR纬 ; peroxisome proliferators-activated receptor 纬 ; PPRE ; PPARs response element ; TCF ; T cell factor ; LEF ; lymphoid-enhancing factor ; RT-PCR ; reverse transcriptase-polymerase chain reaction ; ChIp ; chromatin immunoprecipitation
- 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
- 出版年：July 2014
- 年：2014
- 卷：1840
- 期：7
- 页码：2361-2372
- 全文大小：1275 K
文摘
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180">PPAR纬 mediates the anticancer role of Cladosporol A by the increase of p21waf1/cip1.
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185">Upregulation of p21waf1/cip1 gene expression depends on the Sp1/PPAR纬 interaction.
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190">Cladosporol A causes degradation of 尾-catenin and downregulation of target genes.
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195">Cladosporol A-bound PPAR纬 induces also an increase of E-cadherin gene expression.