Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation
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- 作者：Enrique de Alava ; Mariá ; Dolores Lozano ; Iosu Sola ; Angel Panizo ; Miguel A. Idoate ; Carmen Martinez-Isla ; Jeró ; nimo Forteza ; Luis Sierrasesú ; maga ; F. Javier Pardo-Mindan
- 刊名：Human Pathology
- 出版年：1998
- 出版时间：February 1998
- 年：1998
- 卷：29
- 期：2
- 页码：181-184
- 全文大小：5592 K
文摘
We report a case of a 13-year-old girl with soft tissue sarcoma of the hand, which showed muscle and neuroectodermal immunophenotypes. Molecular studies were performed on RNA collected from fine-needle aspiration (FNA) cytology and peripheral blood samples by nested reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis. This biphenotypic tumor showed simultaneous expression of EWS-FLI1 and PAX3-FKHR transcripts, specific of Ewing family tumors and alveolar rhabdomyosarcoma, respectively. Although childhood sarcomas with simultaneous muscle and neural differentiation have been described to have EWS-FLI1 transcripts, there are no reports of tumors with both transcripts. Cytological specimens are a good source of RNA for molecular studies.