Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study

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• 作者：Gü ; lay Karagü ; zel^a ; ^{karaguzelg@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Nil P. Sakarya^b ; Sevgi Bahadır^c ; Selç ; uk Yaman^d ; Ayşenur &Ouml ; kten^a
• 关键词：25-Hydroxyvitamin D ; Children ; Oral vitamin D ; vitiligo
• 刊名：Clinical Nutrition ESPEN
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：15
• 期：Complete
• 页码：28-31
• 全文大小：400 K

文摘

Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients.

Methods

Thirty patients aged 6–17 years with vitiligo and 30 sex- and age-matched apparently healthy controls were included in this prospective study. Size of the vitiligo representative area was estimated using the point counting method and blood samples were obtained at the beginning and month six. By the end of the study, all patients treated with topical tacrolimus for six months and the patients who were vitamin D deficient (n = 14) had been on combination treatment of oral vitamin D and topical tacrolimus. A dose of 1500 IU/day vitamin D was given if the serum 25(OH)D levels <20 ng/ml and 3000 IU/day was given if the levels <10 ng/ml for six months. Serum 25(OH)D levels were measured by high-performance liquid chromatography.

Results

Serum 25(OH)D levels of patients and controls were not significantly different (p > 0.05). Lesion size decreased from 66.1 ± 58.3 cm² to 48.0 ± 52.6 cm² after six months of treatment in patients who received combination treatment (p < 0.001) and increased in patients who received only topical therapy from 34.8 ± 48.1 cm² to 53.5 ± 64.9 cm² (p < 0.01).

Conclusions

Although we did not determine decreased serum 25(OH)D levels in children with vitiligo, we showed that combination treatment with oral vitamin D and topical tacrolimus is more effective in reaching repigmentation than topical tacrolimus alone. Oral vitamin D supplementation might be useful for children with vitiligo who are also deficient in vitamin D.