Functional role of inorganic trace elements in angiogenesis part III: (Ti, Li, Ce, As, Hg, Va, Nb and Pb)
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- 作者：Mohammad Ali Saghiria ; b ; c ; Saghiri@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; saghiri@gmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Jafar OrangicAuthor Vitae ; Armen AsatouriancAuthor Vitae ; Christine M. SorensondAuthor Vitae ; Nader Sheibania ; bAuthor Vitae
- 关键词：As ; arsenic ; FGF-2 ; basic fibroblast growth factor ; BMP-2 ; bone morphogenetic protein-2 ; Ce ; cerium ; COX ; cyclooxygenase ; EC ; endothelial cells ; EPCR ; endothelial cell protein C receptor ; EPCs ; endothelial progenitor cells ; EMT ; epithelial to mesenchymal transition ; ERK ; extracellular signal regulated kinase ; HUVEC ; human umbilical vein endothelial cells ; HIF ; hypoxia-inducible factor ; IAP ; inhibitor-of-apoptosis protein ; IL ; interleukin ; GSK ; glycogen synthase kinase ; Pb ; lead ; Li ; lithium ; MMP
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：290-301
- 全文大小：1215 K
文摘
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Ti surfaces with different topographies and hydrophilicities mediate different cellular responses.
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The anti-angiogenic effect of TiO2 nanoparticles comes from the inhibition of angiogenic processes, and not from cytotoxicity.
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Li affects vasculogenesis but not angiogenesis, supporting the hypothesis that these processes are differently regulated.
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Arsenic has the dual effects on vascular cells and tumor angiogenesis, at low dose promotes, while at high dose inhibits angiogenesis.
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Lead exposure induced IL-8 production and promotes tumor growth and invasion via inducing angiogenesis.