Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C
详细信息 查看全文
- 作者：Laurent Burnier1 ; Amin Boroujerdi1 ; Jose A. Ferná ; ndez ; Jennifer V. Welser-Alves ; John H. Griffin ; Richard Milner ; rmilner@scripps.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALS ; amyotrophic lateral sclerosis ; APC ; activated protein C ; BBB ; blood-brain barrier ; CMH ; chronic mild hypoxia ; EAE ; experimental autoimmune encephalomyelitis ; EPCR ; endothelial protein C receptor ; FOV ; field of view ; MS ; multiple sclerosis ; PAR1 ; protease activated receptor 1 ; ZO-1 ; zonula occludens-1
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：283
- 期：part_PA
- 页码：396-403
- 全文大小：1255 K
文摘
- •
Studied role of APC in chronic mild hypoxia-induced cerebrovascular remodeling
- •
APC blockade flattened the hypoxic-induced vascular remodeling response
- •
APC block abolished increases in endothelial proliferation and vascular density
- •
APC block also abolished induction of angiogenic endothelial α5β1/αvβ3 integrins
- •
Recombinant APC enhanced endothelial proliferation and expanded total vascular area