Thrombin and protein C pathway in peripheral nerve Schwann cells
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- 作者：Orna Geraa ; b ; c ; ornagera@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Efrat Shavit-Steina ; efrat.shavit.stein@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Doron Bushia ; b ; doron.bushi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sagi Harnofd ; sharnof@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marina Ben Shimona ; b ; elgart.marina@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ronen Weissa ; g ; ronenwe@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Valery Goldermana ; b ; valery.rodionov@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Amir Doria ; amir.dori@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Nicola Maggioa ; e ; g ; nicmaggio@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kate Finegolda ; b ; feingoldkate@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Joab Chapmana ; b ; e ; f ; jchapman@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALS ; Amyotrophic Lateral Sclerosis ; aPC ; activated protein C ; Dvl-2 ; dishevelled-2 ; EPCR ; endothelial protein C receptor ; LTP ; long-term potentiation ; MPNST ; malignant peripheral nerve sheath tumors ; NF1 ; Neurofibromatosis type 1 ; PAR1 ; protease-activated receptor 1 ; pERK ; Phosphorylated extracellular signal-related kinase ; PN-1 ; protease nexin-1 ; PNS ; peripheral nervous system ; TM ; thrombomodulin ; TRAP6 ; PAR1 agonist
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：17 December 2016
- 年：2016
- 卷：339
- 期：Complete
- 页码：587-598
- 全文大小：1894 K
文摘
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Cultured Schwann cells secrete prothrombin and express EPCR.
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Peripheral nerves contain Protein C Pathway Components.
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After sciatic injury thrombin and EPCR increase significantly, Schwann cells are probably the main source of these factors.