Distinct roles of prolactin, epidermal growth factor, and glucocorticoids in β-casein secretion pathway in lactating mammary epithelial cells

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• 作者：Ken Kobayashi ; ^{kkobaya@anim.agr.hokudai.ac.jp} ; Shoko Oyama ^{09poyo29@gmail.com} ; Chinatsu Kuki ^{kuki-chinatsu@jnc.co.jp} ; Yusaku Tsugami ^{saku-39@eis.hokudai.ac.jp} ; Kota Matsunaga ^{alistairovereemkmggg@yahoo.co.jp} ; Takahiro Suzuki ^{tsuzuki@anim.agr.hokudai.ac.jp} ; Takanori Nishimura ^{nishi@anim.agr.hokudai.ac.jp}
• 关键词：Prolactin ; Epidermal growth factor ; Glucocorticoid ; Dexamethasone ; β-casein ; Mammary epithelial cell
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：440
• 期：Complete
• 页码：16-24
• 全文大小：2154 K
• 卷排序：440

文摘

Prolactin is indispensable for initiation of β-casein synthesis. Epidermal growth factor up-regulate β-casein expression. Glucocorticoids activate β-casein secretion with enhancing β-casein expression. Prolactin and glucocorticoids change the expression ratio of casein subtypes.