The “lnc” between 3D chromatin structure and X chromosome inactivation

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• 作者：Amy Pandya-Jones ; Kathrin Plath ; ^{KPlath@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：X chromosome inactivation Xist ; Chromosome conformation ; Non-coding RNA ; Heterochromatin
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：56
• 期：Complete
• 页码：35-47
• 全文大小：1792 K

文摘

The long non-coding RNA Xist directs a remarkable instance of developmentally regulated, epigenetic change known as X Chromosome Inactivation (XCI). By spreading in cis across the X chromosome from which it is expressed, Xist RNA facilitates the creation of a heritably silent, heterochromatic nuclear territory that displays a three-dimensional structure distinct from that of the active X chromosome. How Xist RNA attaches to and propagates across a chromosome and its influence over the three-dimensional (3D) structure of the inactive X are aspects of XCI that have remained largely unclear. Here, we discuss studies that have made significant contributions towards answering these open questions.