T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV

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• 作者：William J. Liu^a ; ^b ; ^c ; ^{liujun@ivdc.chinacdc.cn} ; Min Zhao^d ; ^e ; Kefang Liu^a ; ^b ; Kun Xu^d ; ^e ; ^f ; Gary Wong^c ; ^d ; Wenjie Tan^a ; ^b ; George F. Gao^a ; ^c ; ^d ; ^e ; ^f ; ^{gaofu@chinacdc.cn}
• 关键词：SARS-CoV ; MERS-CoV ; Vaccine ; T-cell ; Epitope ; Cross-reactivity
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：82-92
• 全文大小：2174 K
• 卷排序：137

文摘

T-cell epitopes identified throughout the SARS-CoV proteome may act as candidates for vaccine development. Both SARS-CoV and MERS-CoV-recovered donors have had long-lasting memory T-cell immunity. The structures of HLA/SARS-CoV-epitopes illuminate the molecular bases of cellular immunogenicity. Potential cross-T-cell immune reactivities of SARS-CoV and MERS-CoV benefit vaccine development.