Proteomic insight into the effects of the Salmonella ubiquitin ligase SlrP on host cells
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- 作者：Mar Cordero-Alba1 ; 2 ; mmcordero@cnb.csic.es" class="auth_mail" title="E-mail the corresponding author ; Juan José ; Garcí ; a-Gó ; mez1 ; 3 ; jjgarcia@us.es" class="auth_mail" title="E-mail the corresponding author ; Julia Aguilera-Herce jaguilera3@us.es" class="auth_mail" title="E-mail the corresponding author ; Francisco Ramos-Morales ; framos@us.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：SlrP ; Salmonella ; Type III secretion ; iTRAQ ; Cell adhesion
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：8 April 2016
- 年：2016
- 卷：472
- 期：3
- 页码：539-544
- 全文大小：934 K
文摘
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We analyzed HeLa cells proteome in response to Salmonella ubiquitin ligase SlrP.
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Significant differential expression was detected for 37 human proteins.
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The level of corresponding mRNAs was altered for only a fraction of these proteins.
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Cell adhesion and cell migration were altered in SlrP-expressing cells.
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These results could be a guide for future research on SlrP substrates.