Comprehensive Evaluation of Powdered Chinese Herbal Medicines-An Exemplification of Isatidis Radix

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• 作者：Xue Han^a ; ^b ; ^&dagger ; ; Ming-quan Wu^a ; ^b ; ^&dagger ; ; Zhi-rui Yang^a ; ^b ; Ding-kun Zhang^a ; ^b ; Yi Mao^c ; Jin Han^c ; Yin-qiu Huang^a ; ^b ; Yong-feng Zhou^b ; Yan-ling Zhao^c ; ^{zhaoyl2855@yeah.net" class="auth_mail" title="E-mail the corresponding author} ; Jia-bo Wang^b ; ^{pharm_sci@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-he Xiao^d
• 关键词：chemical dissolution ; comprehensive evaluation ; Isatidis Radix ; neuraminidase-based bioassay ; physical characterization ; powdered Chinese herbal medicine
• 刊名：Chinese Herbal Medicines
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：8
• 期：3
• 页码：286-292
• 全文大小：988 K

文摘

Currently, powdered Chinese herbal medicines (CHMs) were mainly evaluated through physical property, chemical dissolution, and bioactivity independently. It could not reflect the quality comprehensively. This paper was to explore and establish a comprehensive evaluation method for powdered CHMs.

Methods

Isatidis Radix was chosen as an exemple. Firstly, powdered Isatidis Radix in different particle size was prepared. Then, their physical properties were characterized. The dissolution of index component epigoitrin was determined, and their antiviral activities were evaluated by neuraminidase-based bioassay.

Results

ra30">As the particle size decreased, powder distribution tended to be uniform, and the dissolution of epigoitrin increased, antiviral activity enhanced. According to cluster analysis of above results, the sequence of evaluation consequence was ultrafine powder S2 (D₉₀: 32.80 ± 0.29) > ultrafine powder S1 (D₉₀: 52.08 ± 0.53) > fine powder S0 (D₉₀: 118.16 ± 0.76) (from the superior to the inferior).

Conclusion

Overall, the comprehensive evaluation for powdered CHMs based on the physical characterization, chemical dissolution, and bioassay could not only be used to evaluate powdered herbs, but also guide the screening and optimization of the particle size of powder.