Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells
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- 作者：Geum-A Lee ; Kyung-Chul Choi ; kchoi@cbu.ac.kr ; Kyung-A Hwang ; hka9400@naver.com
- 关键词：EDC ; endocrine disrupting chemical ; ER ; estrogen receptor ; EMT ; epithelial-mesenchymal transition ; E1 ; estrone ; E2 ; 17β-estradiol ; E3 ; estriol ; EREs ; estrogen response elements
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：49
- 期：Complete
- 页码：48-57
- 全文大小：4390 K
- 卷排序：49
文摘
TCS promoted cell proliferation, migration, and invasion of breast cancer cells through ER.. TCS increased the protein expression of EMT and metastasis-promoting genes through ER.. Kaempferol suppressed E2 or TCS-induced cell migration and invasion of MCF-7 cells.. Kaempferol reduced the protein expressions of metastasis-promoting genes induced by E2 or TCS..