Immunomodulation by the estrogen metabolite 2-methoxyestradiol
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- 作者：Alexandra Stubelius ; alexandra.stubelius@rheuma.gu.se" class="auth_mail ; Malin C. Erlandsson malin.erlandsson@rheuma.gu.se" class="auth_mail ; Ulrika Islander ulrika.islander@rheuma.gu.se" class="auth_mail ; Hans Carlsten hans.carlsten@rheuma.gu.se" class="auth_mail
- 关键词：E2 ; 17尾-Estradiol ; 2me2 ; 2-Methoxyestradiol ; COMT ; Catechol-O-methyltransferase ; ERs ; Estrogen receptors ; ERE ; Estrogen response elements ; ovx ; Ovariectomized ; orx ; Orchidectomized ; RA ; Rheumatoid arthritis ; SERM ; Selective estrogen receptor modulators
- 刊名：Clinical Immunology
- 出版年：July 2014
- 年：2014
- 卷：153
- 期：1
- 页码：40-48
- 全文大小：598 K
文摘
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2me2 regulate cells in a tissue-, and dose-dependent manner.
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2me2 is a less potent immune-modulator than E2.
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The higher the concentration of 2me2, the more E2-like effects on immune cells.
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Higher concentrations of 2me2 induce proliferation of estrogen responsive tissues.