Long-term functional sequelae of sacrococcygeal teratoma: a national study in the Netherlands

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• 作者：Joep P.M. Derikx ; Antoine De Backer ; Lé ; on van de Schoot ; Daniel C. Aronson ; Zacharias J. de Langen ; Thelma L. van den Hoonaard ; Nicolaas M.A. Bax ; Frans van der Staak ; L.W. Ernest van Heurn
• 刊名：Journal of Pediatric Surgery
• 出版年：2007
• 出版时间：June 2007
• 年：2007
• 卷：42
• 期：6
• 页码：1122-1126
• 全文大小：98 K

文摘

Long-term functional sequelae after resection of sacrococcygeal teratoma (SCT) are relatively common. This study determines the incidence of these sequelae associated clinical variables and its impact on quality of life (QoL).

lass=""h4"">Patients and methods

Patients with SCT treated from 1980 to 2003 at the pediatric surgical centers in the Netherlands aged more than 3 years received age-specific questionnaires, which assessed parameters reflecting bowel function (involuntary bowel movements, soiling, constipation), urinary incontinence, subjective aspect of the scar, and QoL. These parameters were correlated with clinical variables, which were extracted from the medical records. Risk factors were identified using univariate analysis.

lass=""h4"">Results

Of the 99 posted questionnaires, 79 (80 % ) were completed. The median age of the patients was 9.7 years (range, 3.2-22.6 years). There were 46 % who reported impaired bowel function and/or urinary incontinence (9 % involuntary bowel movements, 13 % soiling, 17 % constipation), and 31 % urinary incontinence. In 40 % , the scar was cosmetically unacceptable. Age at completion of the questionnaire, Altman classification, sex, and histopathology were not risk factors for any long-term sequelae. Size of the tumor (>500 cm³) was a significant risk factor for cosmetically unacceptable scar (odds ration [OR], 4.73; confidence limit [CL], 1.21-18.47; P = .026). Long-term sequelae were correlated with diminished QoL.

lass=""h4"">Conclusion

A large proportion of the patients with SCT have problems with defecation, urinary incontinence, or a cosmetically unacceptable scar that affects QoL. Patients who are at higher risk for the development of long-term sequelae cannot be clearly assessed using clinical variables.