PELP1: Structure, biological function and clinical significance
详细信息 查看全文
- 作者：Gangadhara Reddy Sareddy ; Ratna K. Vadlamudi ; vadlamudi@uthscsa.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP1 ; activator protein 1 ; AR ; androgen receptor ; CBP ; CREB- binding protein ; CDK ; cyclin-dependent kinase ; DDR ; DNA damage response ; E2F ; E2F transcription factor 1 ; EGF ; epidermal growth factor ; EGFR ; EGF receptor ; ESR1 ; estrogen receptor alpha ; ESR2 ; Estrogen receptor beta ; ERRα ; estrogen-related receptor α ; FHA ; forkhead-associated ; FHL2 ; four and a half LIM domains 2 ; GR ; glucocorticoid receptor ; GSK3β ; glycogen synthase kinase 3 beta ; HDAC2 ; histone deacetylase 2 ; HRS ; hepatocyte growth fac
- 刊名：Gene
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：585
- 期：1
- 页码：128-134
- 全文大小：563 K
文摘
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein that functions as a coregulator of several transcription factors and nuclear receptors. Notably, the PELP1 protein has a histone-binding domain, recognizes histone modifications and interacts with several chromatin-modifying complexes. PELP1 serves as a substrate of multitude of kinases, and phosphorylation regulates its functions in various complexes. Further, PELP1 plays essential roles in several pathways including hormonal signaling, cell cycle progression, ribosomal biogenesis, and the DNA damage response. PELP1 expression is upregulated in several cancers, its deregulation contributes to therapy resistance, and it is a prognostic biomarker for breast cancer survival. Recent evidence suggests that PELP1 represents a novel therapeutic target for many hormonal cancers. In this review, we summarized the emerging biological properties and functions of PELP1.