Circulating microparticle signature in coronary and peripheral blood of ST elevation myocardial infarction patients in relation to pain-to-PCI elapsed time
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- 作者：R. Suadesa ; 1 ; T. Padró ; a ; 1 ; J. Crespoa ; 1 ; I. Ramaiolaa ; 1 ; V. Martin-Yusteb ; 1 ; M. Sabaté ; b ; 1 ; J. Sans-Roselló ; c ; 1 ; A. Sionisc ; 1 ; L. Badimona ; d ; 1 ; lbadimon@csic-iccc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACS ; acute coronary syndrome ; AUC ; area under the curve ; AV ; annexin V ; CAD ; coronary artery disease ; cMP ; circulating microparticle ; CV ; cardiovascular ; ECs ; endothelial cells ; eMPs ; endothelial-derived microparticles ; ErMPs ; erythrocyte-derived microparticles ; FH ; familial hypercholesterolemia ; gMPs ; granulocyte-derived microparticles ; IQR ; interquartile range ; IT ; ischemic time ; LMPs ; leukocyte-derived microparticles ; ℓMPs ; lymphocyte-derived microparticles ; mAbs ; monoclonal antibodies ; MI ; m
- 刊名：International Journal of Cardiology
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：202
- 期：Complete
- 页码：378-387
- 全文大小：1035 K
文摘
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STEMI patients show changes in circulating microparticle (cMP) signature.
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Prothrombotic and proinflammatory cMPs vary both at systemic and coronary levels.
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The cMP intracoronary profile associates to duration of pain-to-PCI ischemic time.
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Peripheral cMPs associate to the number of diseased vessels.
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cMPs may be considered as sensitive prognostic multi-biomarkers in STEMI.