Circulating microparticles in severe preeclampsia

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• 作者：Fabiana K. Marques^a ; Fernanda M.F. Campos^b ; Olindo A.M. Filho^b ; Andrea T. Carvalho^b ; Luci M.S. Dusse^c ; Karina B. Gomes^a ; ^c ; ^{karinabgb@gmail.com}
• 关键词：Coagulation ; Inflammation ; Microparticles ; Preeclampsia
• 刊名：Clinica Chimica Acta
• 出版年：2012
• 出版时间：24 December, 2012
• 年：2012
• 卷：414
• 期：Complete
• 页码：253-258
• 全文大小：475 K

文摘

The present study aimed to evaluate microparticles (MPs) from different sources in women with severe preeclampsia (PE) compared with normotensive pregnant women and non-pregnant women. This case-control study evaluated 28 pregnant women with severe PE, 30 normotensive pregnant women, and 29 non-pregnant women. MPs from neutrophils, endothelial cells, monocytes, platelets, leukocytes, erythrocytes, and syncytiotrophoblast were evaluated using flow cytometry. A higher total number of MPs were observed in women with severe PE compared with normotensive pregnant women and non-pregnant women (P = 0.004 and P = 0.001, respectively). MPs derived from erythrocytes were increased in women with severe PE compared with normotensive pregnant women (P = 0.002). A trend towards association was observed between platelet count and the number of MPs derived from platelets (P = 0.09) in severe PE group. A positive correlation was also found between the number of endothelial cell-derived MPs and the number of platelet-derived MPs, leukocyte-derived MPs, neutrophil-derived MPs, and lymphocyte-derived MPs (P < 0.05) in severe PE pregnant women. MP counts can be increased in severe PE, and erythrocyte and endothelial cell-derived MPs seem to be associated to severe PE.